Background and aims While vigorous physical activity (VPA) is known to provide greater health benefits per unit time than moderate activity. This study examined associations between the proportion of VPA (%VPA) relative to total volume of PA and the incidence of multiple chronic disease outcomes. Methods This prospective population-based cohort Read more
For decades, nutrition debates have often focused on a single question: Is a low-fat diet or a low-carbohydrate diet better for health and weight loss? A low-fat diet typically reduces total fat intake, especially saturated fats, and emphasizes foods such as fruits, vegetables, whole grains, legumes, and lean proteins. Historically, Read more
This Cochrane review evaluated the benefits and harms of aspirin and other NSAIDs for the primary prevention of colorectal cancer (CRC) and colorectal adenoma (CRA) in the general population. The question is clinically important given long-standing uncertainty about aspirin’s cancer-preventive effects and well-established bleeding risks. The review included 10 randomized Read more
There has been different recommendations about the daily step count needed for multiple better health outcomes. Approximately there are about 1200 – 1500 steps for 1 Km and therefore 7000 steps will be walking about 5 km This systematic review and dose–response meta-analysis synthesised contemporary evidence on the relationship between Read more
Moderate coffee and tea intake shows associations with lower dementia risk and better cognitive function. Evidence from large cohort studies and meta-analyses supports these links, particularly for caffeinated varieties at specific doses. Dementia Risk Reduction Higher caffeinated coffee consumption (top vs. bottom quartile) links to 18% lower dementia risk (HR Read more
Background: Longer effects of multivitamin-mineral (MVM) supplementation on late-life cognitive function remain untested using in-person, detailed neuropsychological assessments. Furthermore, insufficient evidence exists for healthcare providers to recommend daily MVM supplements to prevent cognitive decline. The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) (Ref-1) at Brigham and Women’s Hospital, an affiliate Read more
This Cochrane systematic review examined whether intensive blood pressure (BP) targets provide additional clinical benefit compared with standard BP targets in adults with both hypertension and chronic kidney disease (CKD). While BP lowering is known to improve outcomes in hypertension, the optimal target in CKD remains uncertain and controversial. The Read more
There are various techniques recommended for weight loss. Intermittent fasting is one such method. This Cochrane systematic review assessed whether intermittent fasting (IF) is more effective than traditional dietary advice or no intervention for weight loss in adults living with overweight or obesity. IF strategies included time-restricted eating, alternate-day fasting, Read more
An estimated 200 million people are affected worldwide. In 2017, the WHO formally designated scabies a neglected tropical disease and in 2020 integrated this condition into the WHO roadmap for neglected tropical diseases 2021–30, as part of the Sustainable Development Goals. This double-blind RCT compared topical permethrin 5% with benzyl Read more
Vitamin D is a well-established component of bone metabolism. However, the efficacy and safety of vitamin D supplementation for the prevention of fractures in elderly healthy individuals is still unclear This meta-analysis evaluated whether vitamin D supplementation reduces fracture risk in healthy adults aged ≥60 years without osteoporosis or other Read more