Antibiotics-first strategy for uncomplicated acute appendicitis in adults: A systematic review with meta-analysis of randomized controlled trials LINK BACKGROUND: Acute appendicitis is the most common surgical diagnosis in young patients, with lifetime prevalence of about 7%. Debate remains on whether uncomplicated AA should be operated or not. Aim of this meta-analysis of randomized controlled trials was to assess current evidence on antibiotic treatment for uncomplicated AA compared to standard surgical treatment. METHODS: Systematic literature search was performed using PubMed, EMBASE, Medline, Google Scholar and Cochrane Central Register of Controlled Trials databases for randomized controlled trials comparing antibiotic therapy (AT) and
Prostate Cancer Screening Final Recommendation 2018 The U.S. Preventive Services Task Force (USPSTF or Task Force) has reviewed the evidence on PSA-based screening for prostate cancer and published its final recommendation. The Task Force is deeply committed to a clear and transparent recommendation development process and this final recommendation was informed by comments we received on our draft recommendation from experts, stakeholders and the public. The Task Force recommends men ages 55 to 69 make an individual decision about prostate cancer screening with their clinician. The Task Force recommends against routine screening for men age 70 and older.
Introduction During the past few years the use of statins in primary prevention has come under scrutiny. In 2015 the UK chief medical officer asked the Academy of Medical Sciences to review of drug evaluation in wake of statins controversy [Ref]. The current recommendations from the US Preventive Services Task Force [link] is given below. In addition the ALLHAT RCT reports the ‘Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults’ [Ref]. If you prefer some concise evidence based recommendations from a family practice journal the AFP article would be helpful [Ref]