BACKGROUND Generative artificial intelligence (Gen-AI) chatbots hold promise for building highly personalized, effective mental health treatments at scale, while also addressing user engagement and retention issues common among digital therapeutics. METHODS A RCT with (N=210) with clinically significant symptoms of major depressive disorder (MDD), generalized anxiety disorder (GAD), or at Read more
American Gastroenterological Association (AGA) guidelines are the first to make priority recommendations for antiobesity medication selection on the basis of available evidence from individual agent trials explicitly recommending the use of (a) semaglutide 2.4 mg because of the magnitude of clinical benefit (b) next prioritize liraglutide 3.0 mg, followed by Read more
International guidelines support the use of diet based interventions as front line therapy from increased soluble fiber to more general dietary changes (eg, NICE guidance, low-FODMAP diet). Guidelines overall support psychological and behavior based interventions with caveats to patient selection and differing suggestions for where these should be positioned. Complementary Read more
Antidepressants are commonly used to treat low back pain and spine‐related leg pain. However, their benefits and harms are uncertain. The Cochrane review included 26 randomised controlled trials. Eighteen studies included 2535 participants with non‐specific low back pain, seven studies included 329 participants with spine‐related leg pain, and one study Read more