International guidelines support the use of diet based interventions as front line therapy from increased soluble fiber to more general dietary changes (eg, NICE guidance, low-FODMAP diet). Guidelines overall support psychological and behavior based interventions with caveats to patient selection and differing suggestions for where these should be positioned. Complementary Read more
Antidepressants are commonly used to treat low back pain and spine‐related leg pain. However, their benefits and harms are uncertain. The Cochrane review included 26 randomised controlled trials. Eighteen studies included 2535 participants with non‐specific low back pain, seven studies included 329 participants with spine‐related leg pain, and one study Read more
Omega-3 fatty acids have been used in the treatment and prevention of coronary artery disease, although current evidence suggests they may be of limited benefit. Peripheral arterial disease and coronary artery disease share a similar pathogenesis The Cochrane Review had 15 RCTs (1830 participants) comparing omega-3 fatty acid supplementation with Read more